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Posted by on May 15, 2013 in In progress |

What Is Diamine Oxidase?

The main enzyme for metabolism of ingested histamine is diamine oxidase (DAO) (1–5). An impaired histamine degradation based on a reduced DAO activity and the resulting excess of histamine may cause numerous symptoms mimicking an allergic reaction. In mammals, DAO expression is restricted to specific
tissues; the highest activities are shown for small bowel and
colon ascendens (4, 5, 33) and for placenta and kidney (28, 31).
Lower DAO activity has been discussed as a potential indicator
of intestinal mucosa damage in inflammatory and neoplastic
diseases

Extracellular scavenger of histamine and other diamines by
oxidative deamination of the primary amino group of
histamine

pdf is here http://ajcn.nutrition.org/content/85/5/1185.full.pdf