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Posted by on May 15, 2013 in In progress |

What Is Diamine Oxidase?

The main enzyme for metabolism of ingested histamine is diamine oxidase (DAO) (1–5). An impaired histamine degradation based on a reduced DAO activity and the resulting excess of histamine may cause numerous symptoms mimicking an allergic reaction. In mammals, DAO expression is restricted to specific
tissues; the highest activities are shown for small bowel and
colon ascendens (4, 5, 33) and for placenta and kidney (28, 31).
Lower DAO activity has been discussed as a potential indicator
of intestinal mucosa damage in inflammatory and neoplastic

Extracellular scavenger of histamine and other diamines by
oxidative deamination of the primary amino group of

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