Pages Menu
Categories Menu

Posted by on Jun 14, 2013 in Medical Journals |

Update on diagnosis and treatment of mastocytosis.

Head for The Masto Townhall forum to debate this paper.
This article may be copyrighted. Notice to copyright holders.
You can view the full article at the publisher here
There is a fee associated with downloading this article.
Curr Allergy Asthma Rep. 2011 Aug;11(4):292-9. doi: 10.1007/s11882-011-0199-2.

Update on diagnosis and treatment of mastocytosis.

Brockow K, Ring J.


Mastocytosis is a disorder characterized by increased numbers of mast cells in tissues. Recent clinical observations highlight the association of mastocytosis with an increased risk of anaphylaxis and underline the diversity of this disease. At the molecular level, recent studies have attempted to unravel specific gene expression profiles for activating c-kit mutations in the etiology of mastocytosis. The diagnosis may be facilitated by surrogate markers and detection of aberrant immunophenotypic surface markers. New therapeutic strategies are in development based on intracellular signal pathways, or on application of topical treatments, as are novel forms of cytoreductive therapy, including tyrosine kinase inhibitors.

PMID: 21523372 [PubMed – indexed for MEDLINE]