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Posted by on Jun 14, 2013 in Medical Journals |

The mast cell in interstitial cystitis: role in pathophysiology and pathogenesis.

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Urology. 2007 Apr;69(4 Suppl):34-40.

The mast cell in interstitial cystitis: role in pathophysiology and pathogenesis.

Sant GR, Kempuraj D, Marchand JE, Theoharides TC.

Abstract

Current evidence from clinical and laboratory studies confirms that mast cells play a central role in the pathogenesis and pathophysiology of interstitial cystitis (IC). In this article, we focus on the role of the mast cell in IC and examine the ways in which mast cells and other pathophysiologic mechanisms are interrelated in this disease. Identifying the patients with IC who have mast cell proliferation and activation will enable us to address this aspect of disease pathophysiology in these individuals with targeted pharmacotherapy to inhibit mast cell activation and mediator release.

PMID: 17462477 [PubMed – indexed for MEDLINE]