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Posted by on Jun 14, 2013 in Medical Journals |

Systemic mastocytosis.

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Hematol Oncol Clin North Am. 2011 Oct;25(5):1067-83, vii. doi: 10.1016/j.hoc.2011.09.012.

Systemic mastocytosis.

George TI, Horny HP.

Abstract

An unusual disease, mastocytosis challenges the pathologist with a variety of morphologic appearances and heterogeneous clinical presentations ranging from skin manifestations (pruritus, urticaria, dermatographism) to systemic signs and symptoms indicative of mast cell mediator release, including flushing, hypotension, headache, and anaphylaxis among others. In this article, we focus on recognizing the cytology, histopathology, clinical features, and prognostic implications of systemic mastocytosis, a clonal and neoplastic mast cell proliferation infiltrating extracutaneous organ(s) with or without skin involvement. Diagnostic pitfalls are reviewed with ancillary studies to help unmask the mast cell and exclude morphologic mimics.

Copyright © 2011 Elsevier Inc. All rights reserved.

PMID: 22054735 [PubMed – indexed for MEDLINE]