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Posted by on May 15, 2013 in The Drugs |

Prednisolone (Corticosteroid)

Prednisolone (Corticosteroid)

The information below is reproduced as found on the NHS Choices site as of May 15, 2013 and is presented here for your convenience only. We cannot accept liability for any errors therein and cannot certify that this information is up to date. Please refer to the original site for confirmation.

Information specific to: prednisolone 1mg tablets when used in allergic conditions.

Prednisolone (pred-nisso-loan) is a medicine which is used in inflammatory and allergic disorders.

The information in this Medicine Guide for prednisolone varies according to the condition being treated and the particular preparation used.

Your medicine

Prednisolone is a corticosteroid. Prednisolone works by preventing or reducing inflammation. It is used to treat a number of conditions that are characterised by excessive inflammation.

Prednisolone suppresses the immune system and so can be used to treat autoimmune diseases. Prednisolone can help to prevent and to treat the rejection of transplantedorgans. It can also be used in the treatment of certain types of cancers.

People who take corticosteroids for a long period of time are prone to infections as their immune system can become weak. These infections may be much more severe than they usually would be and the symptoms that would usually be used to identify such infections can be hidden. For this reason people who take Prednisolone must be careful to avoid exposure to infections such as chickenpox and measles whenever possible. If you have been exposed to chickenpox or measles, you must get immediate medical advice. You should continue to take your medicine unless your prescriber advises you to stop taking it.

Other information about Prednisolone:

  • if you have been given a steroid warning card, make sure you carry it with you at all times while you are taking corticosteroids. These cards are normally given to you by your prescriber or by your pharmacist. If you are currently taking corticosteroids, or have taken them in the last year, you must tell everyone involved in prescribing you medicines and giving you medical treatment. This includes your doctor, dentist, nurse and pharmacist. You must make sure that they all know about your corticosteroid treatment.

Do not share your medicine with other people. It may not be suitable for them and may harm them.

The pharmacy label on your medicine tells you how much medicine you should take. It also tells you how often you should take your medicine. This is the dose that you and your prescriber have agreed you should take. You should not change the dose of your medicine unless you are told to do so by your prescriber.

If you feel that the medicine is making you unwell or you do not think it is working, then talk to your prescriber.

Whether this medicine is suitable for you

Prednisolone is not suitable for everyone and some people should never use it. Other people should only use it with special care. It is important that the person prescribing this medicine knows your full medical history.

Your prescriber may only prescribe this medicine with special care or may not prescribe it at all if you:

  • are allergic or sensitive to or have had a reaction to any of the ingredients in the medicine
  • are elderly
  • have an infection
  • have been exposed to chickenpox or shingles while you are taking Prednisolone
  • have diabetes or a family history of diabetes
  • have epilepsy
  • have glaucoma or a family history of glaucoma
  • have had muscle problems caused by taking steroids
  • have had psychoses caused by steroids
  • have heart problems
  • have high blood pressure
  • have hypothyroidism
  • have kidney problems
  • have liver problems
  • have or have had affective disorders
  • have or have had tuberculosis
  • have osteoporosis
  • have peptic ulcers
  • have recently had a heart attack

Furthermore the prescriber may only prescribe this medicine with special care or may not prescribe it at all for a child.

As part of the process of assessing suitability to take this medicine a prescriber may also arrange tests:

  • to check that this medicine is having the desired effect

Over time it is possible that Prednisolone can become unsuitable for some people, or they may become unsuitable for it. If at any time it appears that Prednisolone has become unsuitable, it is important that the prescriber is contacted immediately.


Alcohol can interact with certain medicines.

In the case of Prednisolone:

  • there are no known interactions between alcohol and Prednisolone


Medicines can interact with certain foods. In some cases, this may be harmful and your prescriber may advise you to avoid certain foods.

In the case of Prednisolone:

  • there are no specific foods that you must exclude from your diet when taking Prednisolone

Driving and operating machinery

When taking any medicine you should be aware that it might interfere with your ability to drive or operate machinery safely.

Like all medicinesPrednisolone can cause side effects. You should see how this medicine affects you and then judge if you are safe to drive or operate machinery. If you are in any doubt, talk to your prescriber.

Family planning and pregnancy

Most medicines, in some way, can affect the development of a baby in the womb. The effect on the baby differs between medicines and also depends on the stage of pregnancy that you have reached when you take the medicine.

In the case of Prednisolone:

  • you should only take this medicine during pregnancy if your doctor thinks that you need it

You need to discuss your specific circumstances with your doctor to weigh up the overall risks and benefits of taking this medicine. You and your doctor can make a decision about whether you are going to take this medicine during pregnancy.

If the decision is that you should not have Prednisolone, then you should discuss whether there is an alternative medicine that you could take during pregnancy.


Certain medicines can pass into breast milk and may reach your baby through breast-feeding.

In the case of Prednisolone:

  • you should only take this medicine while breast-feeding if your doctor thinks you need it

Before you have your baby you should discuss breast-feeding with your doctor or midwife. They will help you decide what is best for you and your baby based on the benefits and risks associated with this medicine. You should only breast-feed your baby while taking this medicine on the advice of your doctor or midwife.

Taking other medicines

If you are taking more than one medicine they may interact with each other. At times your prescriber may decide to use medicines that interact, in other cases this may not be appropriate.

The decision to use medicines that interact depends on your specific circumstances. Your prescriber may decide to use medicines that interact, if it is believed that the benefits of taking the medicines together outweigh the risks. In such cases, it may be necessary to alter your dose or monitor you more closely.

Tell your prescriber the names of all the medicines that you are taking so that they can consider all possible interactions. This includes all the medicines which have been prescribed by your GP, hospital doctor, dentist, nurse, health visitor, midwife or pharmacist. You must also tell your prescriber about medicines which you have bought over the counter without prescriptions.

The following medicines may interact with Prednisolone:

  • acetazolamide
  • aminoglutethimide
  • amphotericin
  • aspirin
  • bambuterol
  • carbamazepine
  • ciclosporin
  • digitalis
  • fenoterol
  • formoterol
  • indinavir
  • insulin
  • isoniazid
  • ketoconazole
  • mifepristone
  • phenobarbital
  • phenytoin
  • primidone
  • reproterol
  • rifabutin
  • rifampicin
  • ritodrine
  • ritonavir
  • salbutamol
  • salmeterol
  • somatropin
  • terbutaline
  • thalidomide
  • theophylline
  • tulobuterol

The following types of medicine may interact with Prednisolone:

  • anticoagulants
  • antihypertensives
  • cardiac glycosides
  • diuretics
  • hypoglycaemics
  • intrauterine devices
  • liver enzyme inducers
  • neuromuscular blockers
  • non-steroidal anti-inflammatories
  • oestrogens
  • salicylates
  • vaccines

If you are taking Prednisolone and one of the above medicines or types of medicines, make sure your prescriber knows about it.

Complementary preparations and vitamins

Medicines can interact with complementary preparations and vitamins. In general, there is not much information available about interactions between medicines and complementary preparations or vitamins.

If you are planning to take or are already taking any complementary preparations and vitamins you should ask your prescriber whether there are any known interactions with Prednisolone.

Your prescriber can advise whether it is appropriate for you to take combinations that are known to interact. They can also discuss with you the possible effect that the complementary preparations and vitamins may have on your condition.

If you experience any unusual effects while taking this medicine in combination with complementary preparations and vitamins, you should tell your prescriber.

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Information specific to: prednisolone 1mg tablets when used in allergic conditions.

Ingredients of your medicine

Medicines contain active ingredients. They may also contain other, additional ingredients that help ensure the stability, safety and effectiveness of the medicine. They are also added to improve the medicine's taste and appearance and to make it easier to take. Some may be used to prolong the life of the medicine.

This medicine contains prednisolone.

We are unable to list all of the ingredients for your medicine here. For a full list, you should refer to the patient information leaflet that comes with this medicine. You should check that you are able to take the ingredients of your medicine, especially if you have any allergies. You should also check whether any of these ingredients are known to have side-effects.

If you are not able to take any of the ingredients in your medicine, talk to your prescriber or pharmacist to see if they can suggest an alternative medicine. If you have reacted badly to Prednisolone before, do not take Prednisolone. Talk to your prescriber, pharmacist or nurse as soon as possible.

How to take your medicine

Some medicines have specific instructions about how to take them. This is because they work better when taken correctly. These instructions can include getting the right dose and special instructions for preparing the medicine.

Specific information on how to take Prednisolone can be found in the Patient Information Leaflet that comes with this medicine or on the medicinelabel. Alternatively, you can request information about how to take your medicine from your doctor or pharmacist.

If you are having problems taking this form of Prednisolone, you should talk to your prescriber or pharmacist. They may be able to give you advice on other ways to take your medicine or other preparations that are easier for you to take.

When to take your medicine

Some medicines work best if they are taken at a specific time of day. Getting the most benefit from your medicine can also be affected by what you eat, when you eat and the times at which you take other medicines.

Specific information on when to take Prednisolone can be found in the Patient Information Leaflet that comes with this medicine or on the medicinelabel. You can also ask your doctor or pharmacist for information about when to take your medicine.

Taking too much of your medicine

Taking extra doses of some medicines can be harmful. In some cases even one extra dose can cause you problems. If you take extra doses of your medicine, you must get medical advice immediately. You may need a test to assess the effect of taking extra doses. This is because the effects of taking too much medicine are very complex so it is very important that you seek medical advice.

Contact your prescriber, pharmacist, specialist clinic or NHS Direct on 0845 46 47 for advice.

Make sure you take all of your medicinecontainers with you if you are advised to go to hospital.

Stopping your medicine

If you are not having any problems taking this medicine then do not stop taking it, even if you feel better, unless advised to do so by your prescriber. If, however, you find that this medicine is causing you problems then you should talk to your prescriber about your concerns.

If your medical team decides that it is best that you do not take this medicine any more, they may advise that you do not stop Prednisolone abruptly. This is because, in some instances, stopping Prednisolone abruptly can cause withdrawal symptoms or cause your original condition to return. In these instances, reducing the dose of Prednisolone gradually over time may reduce the chances of having these problems.

If you are in any doubt, contact your prescriber, pharmacist, specialist clinic or NHS Direct on 0845 46 47.

Looking after your medicine

The instructions on how you should keep your medicine are on the pharmacy label. It is a good idea to keep your medicine in the original container. This will help to keep your medicine in the best condition and also allow you to check the instructions. Do not take the medicine if the packaging appears to have been tampered with or if the medicine shows any signs of damage. Make sure that the medicine is out of the sight and reach of children.

Specific information on how to look after Prednisolone can be found in the Patient Information Leaflet that comes with this medicine or on the medicinelabel. Alternatively, you can request information about how to look after your medicine from your doctor or pharmacist.

You must not take the medicine after the expiry date shown on the packaging. If you have any unused medicine, return it to your pharmacist who will dispose of it safely.

Content provided by Datapharm

Information specific to: prednisolone 1mg tablets when used in allergic conditions.


A medicine is only made available to the public if the clinical trials have shown that the benefits of taking the medicine outweigh the risks.

Once a medicine has been licensed, information on the medicine's effects, both intended and unintended, is continuously recorded and updated.

Some side-effects may be serious while others may only be a mild inconvenience.

Everyone's reaction to a medicine is different. It is difficult to predict which side-effects you will have from taking a particular medicine, or whether you will have any side-effects at all. The important thing is to tell your prescriber or pharmacist if you are having problems with your medicine.

The frequency of these side-effects is unknown

  • abnormal laboratory test results
  • acne
  • adrenal problems
  • amenorrhoea
  • appetite gain
  • behavioural changes
  • blindness
  • blood problems
  • bone fractures
  • bruising
  • changes in emotions
  • confusion
  • Cushing's syndrome or cushing-likesymptoms
  • decreased carbohydrate tolerance – this may lead to an increased requirement for anti-diabetic therapy
  • delirium
  • depression
  • diabetes
  • euphoria
  • eye or eyesight problems
  • fattening of the upper back and neck
  • feeling anxious
  • feeling dizzy
  • feeling nervous
  • feeling restless
  • flushing
  • gastrointestinal problems such as peptic ulcers
  • hair overgrowth
  • hallucinations
  • headaches
  • healing problems
  • heart problems
  • hiccups
  • hiding symptoms of infection
  • high levels of cholesterol or other lipids in the blood
  • hypersensitivity reactions such as anaphylaxis
  • increased blood sugar levels
  • increased risk of getting infections which may become severe – some of these such as chickenpox may be fatal
  • increased sweating
  • indigestion
  • intracranial hypertension
  • irregular menstrual periods
  • mania or mania-like behaviour
  • memory problems
  • metabolic problems
  • muscle problems
  • muscle weakness
  • nausea
  • oedema
  • osteonecrosis
  • osteoporosis
  • pancreatitis
  • Prednisolonedependence
  • psychiatric problems -seek immediate medical advice if symptoms such as feeling irritable, euphoria, depressed and labile mood or thoughts of committing suicide occur
  • psychotic-like behaviour such as mania, delusions, hallucinations and worsening of schizophrenia
  • raised blood pressure
  • reactivation of tuberculosis
  • reduced growth
  • return of the condition that Prednisolone is being used to treat
  • skin problems
  • sleeping problems
  • Stevens-Johnson syndrome
  • striae
  • telangiectasia
  • tendon rupture
  • thinning of the skin
  • thromboembolism
  • toxic epidermal necrolysis
  • tumour lysis syndrome
  • water retention
  • weight gain
  • withdrawal symptoms can occur when this medicine is stopped. These include vomiting, weakness, emotional changes, nausea, intracranial hypertension, dizziness, headache, reappearance of diseasesymptoms, changes to mental state, fever, musclepain, jointpain, rhinitis, conjunctivitis, weight loss or painful, itchy skin. If the dose of Prednisolone is reduced too rapidly serious problems can occur including adrenal problems, lowered blood pressure or death
  • worsening of epilepsy
  • worsening of schizophrenia
  • worsening or reactivation of infections

If you feel unwell or if you have concerns about a side-effect, you will need to seek advice. If you feel very ill, get medical help straight away. Contact your prescriber, pharmacist, nurse or call NHS Direct on 0845 46 47.

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