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Posted by on Jun 14, 2013 in Medical Journals |

Mast cell activation disease: a concise practical guide for diagnostic workup and therapeutic options.

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J Hematol Oncol. 2011 Mar 22;4:10. doi: 10.1186/1756-8722-4-10.

Mast cell activation disease: a concise practical guide for diagnostic workup and therapeutic options.

Molderings GJ, Brettner S, Homann J, Afrin LB.

Abstract

Mast cell activation disease comprises disorders characterized by accumulation of genetically altered mast cells and/or abnormal release of these cells' mediators, affecting functions in potentially every organ system, often without causing abnormalities in routine laboratory or radiologic testing. In most cases of mast cell activation disease, diagnosis is possible by relatively non-invasive investigation. Effective therapy often consists simply of antihistamines and mast cell membrane-stabilising compounds supplemented with medications targeted at specific symptoms and complications. Mast cell activation disease is now appreciated to likely be considerably prevalent and thus should be considered routinely in the differential diagnosis of patients with chronic multisystem polymorbidity or patients in whom a definitively diagnosed major illness does not well account for the entirety of the patient's presentation.

PMID: 21418662 [PubMed – indexed for MEDLINE] PMCID: PMC3069946 Free PMC Article