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Posted by on Jun 14, 2013 in Medical Journals |

Increased leukotriene E4 excretion in systemic mastocytosis.

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Prostaglandins Other Lipid Mediat. 2010 Jun;92(1-4):73-6. doi: 10.1016/j.prostaglandins.2010.03.003. Epub 2010 Apr 7.

Increased leukotriene E4 excretion in systemic mastocytosis.

Butterfield JH.


Cysteinyl leukotrienes such as LTE(4) are produced by mast cells, neutrophils, eosinophils, and macrophages. LTE(4) levels have not been reported in systemic mastocytosis, a disorder with a large increase in mast cell numbers. Urinary LTE(4) from patients referred for symptoms potentially due to mast cell degranulation or systemic mastocytosis was measured by a commercial cysteinyl leukotriene enzyme immunoassay kit. The diagnosis of systemic mastocytosis was established using current World Health Organization criteria. Compared with a control group of patients with various potential mast cell-related symptoms (e.g., “spells”), patients with systemic mastocytosis had a significant (P=.01) increase in urinary LTE(4) excretion, whether expressed as LTE(4) ng/g creatinine or as LTE(4) ng/24h. There was a moderate correlation of LTE(4) ng/24h with excretion of N-methyl histamine and serum tryptase but not with urinary 11beta-prostaglandin F(2alpha) (11beta-PGF(2alpha)) excretion. LTE(4) excretion is increased in patients with systemic mastocytosis and potentially contributes to clinical symptoms.

Copyright 2010 Elsevier Inc. All rights reserved.

PMID: 20380889 [PubMed – indexed for MEDLINE]