Histamine in the neurogenic inflammation.
The term “neurogenic inflammation” has been adopted to describe the local release of inflammatory mediators from neurons such as substance P and calcitonin gene related peptide. Once released, these neuropeptides cause histamine release from adjacent mast cells. In turn, histamine evokes the substance P and calcitonin gene related peptide release, thus a bidirectional link between histamine and neuropeptides in neurogenic inflammation is established. The aim of this review is to summarize the most recent findings on the role of histamine in neurogenic inflammation with particular regards to nociceptive pain as well as neurogenic inflammation in the skin, in the airways and in the bladder.
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