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Posted by on Jun 14, 2013 in Medical Journals |

Dermoscopic features of skin lesions in patients with mastocytosis.

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Arch Dermatol. 2011 Aug;147(8):932-40. doi: 10.1001/archdermatol.2011.190.

Dermoscopic features of skin lesions in patients with mastocytosis.

Vano-Galvan S, Alvarez-Twose I, De las Heras E, Morgado JM, Matito A, Sánchez-Muñoz L, Plana MN, Jaén P, Orfao A, Escribano L.

Abstract

OBJECTIVES:

To evaluate dermoscopic features in a group of 127 patients with mastocytosis in the skin and to investigate the relationship between different dermoscopic patterns and other clinical and biological characteristics of the disease.

DESIGN:

Clinical and laboratory data were compared among patients with mastocytosis grouped according to the different dermoscopic patterns.

SETTING:

Patients were selected from the Instituto de Estudios de Mastocitosis de Castilla La Mancha and the Department of Dermatology of Hospital Universitario Ramón y Cajal from April 1 through September 30, 2009. Patients Overall, 127 consecutive patients (70 females [55.1%] and 57 males [44.9%]; median age, 17 years; range, 0-81 years) with mastocytosis in the skin were included in the study.

MAIN OUTCOME MEASURES:

Evaluation of dermoscopic patterns and investigation of potential predictive factors for more symptomatic forms of the disease according to the need for daily antimediator therapy.

RESULTS:

Four distinct dermoscopic patterns were observed: yellow-orange blot, pigment network, reticular vascular pattern, and (most frequently) light-brown blot. A reticular vascular pattern was identified in all telangiectasia macular eruptiva and some maculopapular mastocytosis. In turn, all patients with mastocytoma displayed the yellow-orange blot pattern. The reticular vascular dermoscopic pattern was associated with the need for daily antimediator therapy; this pattern, together with serum tryptase levels and plaque-type mastocytosis, represented the best combination of independent factors to predict the need for maintained antimediator therapy.

CONCLUSIONS:

Dermoscopy is a feasible method for the subclassification of mastocytosis. Of note, a reticular vascular pattern is more frequently associated with the need for antimediator therapy.

PMID: 21844452 [PubMed – indexed for MEDLINE]