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Posted by on Jun 14, 2013 in Medical Journals |

Classification and response criteria in mastocytosis: is there a need to revise?

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Expert Rev Hematol. 2010 Jun;3(3):247-9. doi: 10.1586/ehm.10.20.

Classification and response criteria in mastocytosis: is there a need to revise?

Valent P.

Abstract

Mastocytosis is a heterogeneous disease characterized by the accumulation of mast cells in one or more organs. Our objective was to identify a peripheral mast cell precursor and assess its variation rate in mastocytosis. A peripheral blood phenotypic analysis was performed among 50 patients with mastocytosis who were enrolled in a prospective multicentric French study, and the phenotypic analysis results of the patients were compared with those of healthy donors. The rate of peripheral blood CD34(-)c-Kit(+) cells correlated with the severity of mastocytosis. This cellular population was isolated from healthy donors as well as from patients with systemic mastocytosis. After 30 days of culture, the CD34(-)c-Kit(+) cells gave birth to mature mast cells, indicating that this cellular population constitutes a mast cell circulating precursor. Monitoring peripheral CD34(-)c-Kit(+) cells by flow cytometry could be a useful and low-invasive tool to determine the disease severity and the relapses and to assess treatment efficiency.

PMID: 21082975 [PubMed – indexed for MEDLINE] Free full text