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Posted by on Jun 14, 2013 in Medical Journals |

Brief report: “allergic symptoms” in children with Autism Spectrum Disorders. More than meets the eye?

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J Autism Dev Disord. 2011 Nov;41(11):1579-85. doi: 10.1007/s10803-010-1171-z.

Brief report: “allergic symptoms” in children with Autism Spectrum Disorders. More than meets the eye?

Angelidou A, Alysandratos KD, Asadi S, Zhang B, Francis K, Vasiadi M, Kalogeromitros D, Theoharides TC.

Abstract

Many children with Autism Spectrum Disorders (ASD) have either family and/or personal history of “allergic symptomatology”, often in the absence of positive skin or RAST tests. These symptoms may suggest mast cell activation by non-allergic triggers. Moreover, children with mastocytosis or mast cell activation syndrome (MCAS), a spectrum of rare diseases characterized by increased number of activated mast cells in many organs, appear to have ASD at a rate tenfold higher (1/10 children) than that of the general population (1/100 children). Mast cell activation by allergic, infectious, environmental and stress-related triggers, especially perinatally, would release pro-inflammatory and neurotoxic molecules. We speculate these could disrupt the gut-blood-brain barriers, thus contributing to brain inflammation and ASD pathogenesis. Increased mast cell responsiveness may define at least a subgroup of ASD subjects, who could benefit from inhibition of mast cell activation.

PMID: 21210299 [PubMed – indexed for MEDLINE]